The most common cause of this particular issue is when Jasperactive is NOT locally installed. Jasperactive is a live-in-the-application (LITA) program, and requires installation before launching Courses.
To see if Jasperactive is correctly installed on your computer, please see our How-To Guide: Jasperactive Update Icon
To install Jasperactive, please see our How-To Guide: Using the Jasperactive Installer